The neurodegeneration of the cholinergic pathways in subtypes of subjective cognitive decline

Background Neurodegeneration of cholinergic pathways may be present in individuals with subjective cognitive decline (SCD). However, variability between SCD the integrity needs to elucidated. Our objective was determine characteristics neurodegeneration different subtypes (i.e. amnestic vs. non-amnestic). Method Individuals (n = 47), non-amnestic 38), and healthy controls without complaints (HC; n 20) from GENIC database were included (all: >60 years old; 58% females). White matter estimated by mean diffusivity (MD) on diffusion tensor imaging (DTI) for cingulum external pathways. Both previously modelled using tractography DTI. Memory performance measured based Visual reproduction WMS-III TAVEC (the Spanish version California Verbal Learning Test, CVLT). ANOVA bivariate Pearson correlation used statistical analysis. Result Amnestic groups comparable HC WM Bivariate analyses showed patterns association cognition within each group. In amnestic-SCD, worse both associated poorer immediate recall visual information (external capsule: rxy -0.42; p<0.05; cingulum: -0.34; p<0.05). non-amnestic-SCD, delayed verbal -0.54; p<0.05); capsule pathway (rxy -0.37; p<0.05 -0.46; HC, none outcomes Conclusion The mainly acquisition new information); whereas several subcomponents memory information). Thus, show unique associations system performance.